The ability of a synapse to change how it responds to stimuli as a result of previous stimuli activity. There are three major forms of homosynaptic plasticity: facilitation, potentiation, and depression.

These differ from heterosynaptic plasticity which describes the change in response to stimuli induced by other cells.

Facilitation, potentiation, and depression (homosynaptic plasticity) may all be exhibited by a single synapse.