A single synapse
can alter its response to a given level of stimulus over time. Some things that may alter a synapse's response to a given level of stimulus include, activity on its own input (habituation
, or homoplasticity), activity on other synapses on its neuron (associative learning
), chemical changes in the immediate area of the synapse, Chemical changes in the nutrient supply to the neuron (hormonal), etc.
A synaptic connection may return to a previous state via resilience.